Josh Hazlewood will be the first bowler rested during the Pakistan one-day series, set to miss Friday's series-opener against Pakistan at the Gabba.
Coach Darren Lehmann announced the move on Sunday as part of a plan to rest both Hazlewood and fellow Test spearhead Mitchell Starc during the five-match ODI series, ahead of next month's key four-Test series in India.
'He (Hazlewood) is not injured but we have decided to give him a week to freshen up at home and he will link up with the ODI squad in Melbourne ahead of the second match of the series,' Lehmann said.
'Although if one of our other fast bowlers picks up an injury in the run-up to Friday's first game at The Gabba then he could be called up to slot in.'
Resting Hazlewood and Starc had always been part of Australian management's plans for the one-day series.
Both delivered more than 250 overs in the six-Test summer, along with a three- match ODI series slotted between the South Africa and Pakistan Tests.
Queensland quick Billy Stanlake is likely to be the beneficiary of the decision to rest Hazlewood, with only four quicks named in the 14-man squad for the series.
Lehmann had earlier confirmed on Saturday that he wanted to play three pacemen at the Gabba, which now opens the door for the 22 year-old to make his Australia debut.
'He's tall, he's fast, he's got some bounce, so that's a pleasing thing for us,' Lehmann said of Stanlake on Saturday.
'It's a good challenge for him. Young kid coming through, exciting times.'
Starc had been limping on day five of the third Test but remained on the field and skipper Steve Smith suggested he was fine.
Lehmann and selectors also won't want to overwork oft-injured tearaway Pat Cummins, who returned from a lay-off of almost 15 months earlier this summer.